Toxicity of Cisplatin and Herbal Medicine Complexed with Bovine Serum Albumin (BSA) and Folic Acid Nanoparticles as Anticancer Candidates

The prevalence of cancer in Indonesia has increased by 8.8 percent the last two years (2018 and 2020) terms adding new cases mortality. Because therefor treatment becomes important reducing high number additional mortality due to patients. Intensive is surgery, chemotherapy, radiotherapy immunotherapy. Chemotherapy drugs used for include herbal plant-based (Cancer Fit) cisplatin its buy from online shop. This study aims compare toxicity fit) with cisplatin, a combination BSA nanoparticles folic acid as anticancer candidates. research method through synthesis desolvation method, then characterization carried out using XRD FT-IR tests. After that proceed test BSLT method. results obtained analysis on (As-NP-BSA-CP) showed peak 34.45 while medicine (As-NP-BSA-Oh) 22.77. purpose was determine crystalline characteristics synthesized analyze index. there are functional groups O-H alcohol, C-H, C-C, NO2 play role nanoparticles. Meanwhile, were C-H alkene, C-O C-N amine/amide. level As-NP-BSA-CP LC50 69.14 ppm As-NP-BSA-Oh 44.14 ppm. Nanoparticles consisting bovine serum albumin (BSA), or can be candidates drugs.